As a Graduate Research Assistant in the Computational Chemodynamics Laboratory (CCL), I work at the frontier of Biology and Mathematical Modeling, using mathematical modeling coupled with computational power to provide insights into the complex interactions of biology and the environment. The research encompasses the entire gamut of processes from exposure estimation (shown in the diagram above in red as MENTOR) to biological effect modeling (shown in blue as DORIAN). Understanding the effect of chemicals requires a detailed understanding of all the processes from source-to-dose-to-effect which will potentially influence how and to what extent a given chemical will affect an individual over time.

My research specifically concerns the circled right half of the diagram, encompassing the fields of toxicokinetic and toxicodynamic modeling, nanotoxicology, and health risk estimation. I have been working for the last few years with various tools of computational biology including Simcyp Pathway Lab, SimBiology, CompuCell 3D and also building customized computational modules using Matlab.

I also use statistical analyses, machine learning, Bayesian parameter estimation, and optimization in various stages of model building and implementation.

Some important software packages used in my research:

Software package	Description	Developer	URL
Matlab	Model development, optimization, simulation	Mathworks Inc.	http://www.mathworks.com/
Simcyp	PBPK model development & simulation	Simcyp Ltd.	http://www.simcyp.com/
R	Statistical analyses, regression, plotting	R Project	http://www.r-project.org/
Pathway Lab	Network Modeling	InNetics AB	http://www.innetics.com/