Modeling population-wide health effects and risks

Just as a human body presents an enthralling level of complexity, so does a human population present a staggering level of variety. Each human being is very different for another in the way the body responds to a certain chemical. One man’s drug is another man’s poison.

PBPK models predicting chemical kinetics in the body would be incomplete if they did not capture the characteristic differences and variety among individuals pertaining to ADME of the chemical.

Specific projects:

• Modeling population-wide exposure and intake of manufactured nanomaterials in the US population
• Analyzing linkages between chemical exposure risk and neurotoxicity in the US population